The ability of human pluripotent stem cells (hPSCs) to differentiate into the many specialized cell types of the human body holds great promise for the study and treatment of human disease. Genome editing of hPSCs can allow for more accurate modeling of human diseases by introducing disease-specific mutations or correcting genetic aberrations in patient-derived induced pluripotent stem cell lines. Advances in genetic tools, such as clustered regularly interspaced short palindromic repeat (CRISPR) technology, have improved the ease and efficiency of genome editing in hPSCs.View this webinar presentation by Dr. Chad Cowan, who discussed his research efforts to understand metabolic disease using the CRISPR/Cas system in human pluripotent stem cells to create genetic disease models.
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