Verteporfin

YAP1 inhibitor

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YAP1 inhibitor
From: 45 USD

Overview

Verteporfin is a benzoporphyrin derivative that inhibits autophagosome formation by directly targeting and modifying p62, a scaffold protein that targets polyubiquitinated proteins for degradation (Donohue et al.). Verteporfin also disrupts YAP-TEAD interactions by enhancing trypsin cleavage of YAP (EC₅₀ = 100 nM; Brodowska et al.; Liu-Chittenden et al.).

CANCER RESEARCH
· Inhibits the growth, proliferation, and viability of human retinoblastoma cells (Brodowska et al.).
· Inhibits self-renewal in cancer stem cells with high YAP1 and ALDH1 levels (Song et al.).
Alternative Names:
BPD-MA; CL 318,952
CAS Number:
129497-78-5
Chemical Formula:
C₄₁H₄₂NO
Molecular Weight:
718.8 g/mol
Purity:
≥ 95%
Target:
p62; YAP1

Scientific Resources

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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.