CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.).
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
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