Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

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Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
From: 224 USD

Overview

Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models.

CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.).

CANCER RESEARCH
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
Alternative Names:
trans-Tamoxifen
CAS Number:
10540-29-1
Chemical Formula:
C₂₆H₂₉NO
Molecular Weight:
371.5 g/mol
Purity:
≥ 95%
Pathway:
Estrogen
Target:
ER

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.