Soluble ICAM-1/CD54, Mouse, Recombinant

Soluble ICAM-1 (CD54)

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Soluble ICAM-1/CD54, Mouse, Recombinant

Soluble ICAM-1 (CD54)

100 µg
Catalog #02203
756 USD

Soluble ICAM-1/CD54, Mouse, Recombinant

Soluble ICAM-1 (CD54)

Catalog #02213
3,031 USD

Overview

Mouse soluble ICAM-1 is a recombinant protein derived from the cell adhesion molecule ICAM-1 (CD54). ICAM-1 has a molecular mass of approximately 95 kDa. It is a membrane protein expressed on many cell types and its expression is upregulated upon cell activation. It binds to two integrins on leukocytes, LFA-1 and Mac-1. Cell adhesion mediated by these molecules is critical for a wide range of cellular interactions in the immune system, including leukocyte adhesion to endothelial cells and interaction between T cells and antigen-presenting cells. The adhesion of leukocytes to ICAM-1 requires functional activation of LFA-1 or Mac-1 on leukocytes. Purified sICAM-1 adsorbed to a solid support binds activated cells expressing LFA-1 or Mac-1, but not resting cells. This binding can be blocked by the monoclonal anti-ICAM-1 antibody (in mouse with clone YN1/1; Catalog #01503), anti-LFA-1 or anti-Mac-1, indicating a direct interaction of these molecules in cell adhesion. Soluble ICAM is useful for the studies of the activation of leukocyte adhesion in immune responses and inflammatory reactions.
Contains:
Supplied in phosphate-buffered saline
Cell Type:
Lymphocytes; T Cells
Species:
Mouse
Area of Interest:
Immunology; Stem Cell Biology

Scientific Resources

Product Documentation

Educational Materials

(1)
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.