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SIS3

Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

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SIS3

Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

From: 73 GBP
Catalog #
73962_C
Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

Overview

SIS3 (specific inhibitor of SMAD3) is a cell-permeable selective inhibitor of transforming growth factor β1 (TGF-β1)-dependent SMAD3 phosphorylation (IC50 = 3 µM) and SMAD3-mediated cellular signaling (Jinnin et al.). SIS3 has no effect on SMAD2, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), or phosphoinositide 3-kinases.


DIFFERENTIATION
· Facilitates the production of anterior ectoderm from mouse induced pluripotent stem cells (Oshima et al.).
· Inhibits myofibroblast differentiation of normal human dermal fibroblasts (Jinnin et al.).
Alternative Names
Smad3 Inhibitor
Cell Type
Neural Cells, PSC-Derived
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Neuroscience
CAS Number
1009104-85-1
Chemical Formula
C₂₈H₂₇N₃O₃
Molecular Weight
453.5 g/mol
Purity
≥ 98%
Pathway
Activin/Nodal/TGFβ
Target
TGFβ

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
SIS3
Catalog #
73962, 73964
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SIS3
Catalog #
73962, 73964
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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