SBI-0206965

ULK1 and ULK2 kinase inhibitor

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ULK1 and ULK2 kinase inhibitor
From: 119 USD

Overview

SBI-0206965 is an inhibitor of the autophagy initiator kinases ULK1 and ULK2 (IC₅₀ = 108 nM and 711 nM, respectively; Egan et al.). SBI-0206965 is also a potent inhibitor of AMP-activated protein kinase (AMPK), a positive regulator of autophagy (Dite et al.).

CANCER RESEARCH
· Synergizes with mTOR inhibition to induce apoptosis and cell death in tumor cells (Egan et al.).
· Suppresses autophagy induced by mTOR inhibition (Egan et al.).
· Suppresses prosurvival autophagic responses in tumor cells through AMPK and ULK1 inhibition (Dite et al.).
CAS Number:
1884220-36-3
Chemical Formula:
C₂₁H₂₁BrNO
Molecular Weight:
489.3 g/mol
Purity:
≥ 98%
Pathway:
mTOR
Target:
ULK1; ULK2

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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.