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SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

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SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

From: 1,088 USD
Catalog #
100-0594_C
SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags
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Overview

SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.
Subtype
Recombinant Proteins
Alternative Names
S protein, Spike glycoprotein
Cell Type
B Cells, Lymphocytes, Plasma, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Infectious Diseases
Purity
≥ 85%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)
Catalog #
100-0594, 100-0595
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)
Catalog #
100-0594, 100-0595
Lot #
All
Language
English

Resources and Publications

Educational Materials (6)

Enabling Life Science Research
Brochure
Enabling Life Science Research
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
ELISA Kits for Immunology Research
Brochure
ELISA Kits for Immunology Research
Modeling Cystic Fibrosis Airway: PneumaCult™-Ex Plus and PneumaCult™-ALI
Brochure
Modeling Cystic Fibrosis Airway: PneumaCult™-Ex Plus and PneumaCult™-ALI
Collaborating to Accelerate COVID-19 Research
3:36
Video
Collaborating to Accelerate COVID-19 Research
Exploring the Impact of SARS-CoV-2 Infection on the Central Nervous System
1:00:11
Webinar
Exploring the Impact of SARS-CoV-2 Infection on the Central Nervous System

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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