SAHA

Epigenetic modifier; Inhibits HDAC1 and HDAC3
Catalog #
73902_C
Epigenetic modifier; Inhibits HDAC1 and HDAC3
From: 68 USD

Overview

SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs). This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow).

REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).

CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).

· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
Alternative Names
Suberoylanilide hydroxamic acid; Vorinostat
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Cancer Research, Disease Modeling, Stem Cell Biology
CAS Number
149647-78-9
Chemical Formula
C₁₄H₂₀N
Molecular Weight
264.3 g/mol
Purity
≥ 98%
Pathway
Epigenetic
Target
HDAC

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
SAHA
Catalog #
73902, 73904
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SAHA
Catalog #
73902, 73904
Lot #
All
Language
English

Educational Materials(5)

Brochure
Small Molecules for Cancer Research
Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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