RSC-133
Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
-
RSC-133 -
RSC-133 -
Label for RSC-133
More Views
Overview
Reprogramming stimulating compound (RSC)-133 is an indole derivative that specifically inhibits DNA methyltransferase DNMT1 (Lee et al.).
REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).
MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).
MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
Alternative Names:
Not applicable
CAS Number:
1418131-46-0
Chemical Formula:
C₁₈H₁₅N₃O₂
Molecular Weight:
305.3 g/mol
Purity:
≥ 95%
Pathway:
Epigenetic
Target:
DNMT
Related Products
-
A non-integrating, self-replicating RNA reprogramming vector for generating iPS cells
Scientific Resources
Product Documentation
Document Type
Product Name
Catalog #
Lot #
Language
Educational Materials
(4)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages for
Workflow Stages
Data and Publications
Publications
(1)
Angewandte Chemie (International ed. in English) 2012
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
Abstract
Abstract
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.