RSC-133

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

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RSC-133

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

10 mg
Catalog #73392
202 USD

Overview

Reprogramming stimulating compound (RSC)-133 is an indole derivative that specifically inhibits DNA methyltransferase DNMT1 (Lee et al.).

REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).

MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
Alternative Names:
Not applicable
CAS Number:
1418131-46-0
Chemical Formula:
C₁₈H₁₅N₃O₂
Molecular Weight:
305.3 g/mol
Purity:
≥ 95%
Pathway:
Epigenetic
Target:
DNMT

Scientific Resources

Product Documentation

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(4)

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Data and Publications

Publications

(1)
Angewandte Chemie (International ed. in English) 2012

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.

Lee J et al.

Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.