Recombinant B18R Protein

B18R protein

Recombinant B18R Protein

B18R protein

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B18R protein
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Overview

The B18R protein, which is encoded by the B18R open reading frame in the Western Reserve (WR) strain of vaccinia virus, is a type I interferon (IFN)-binding protein that is known to inhibit IFN antiviral response (Colamonici et al.). B18R protein has been shown to exhibit neutralizing activity to type I interferon family members (Meyers et al.) and to protect cells from the antiviral effects of interferon (Vancová et al.). It was recently shown that HIV-1–dependent induction of type I IFN activity and BAFF protein levels was abrogated by the soluble B18R protein, with no effect observed on the cell viability (Gomez et al.). B18R protein has been reported to aid in cellular reprogramming using RNA-mediated gene delivery (Warren et al.; Yoshioka N et al.).
Subtype
Cytokines
Cell Type
Pluripotent Stem Cells
Species
Human
Area of Interest
Stem Cell Biology
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78075, 78075.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78075, 78075.1
Lot #
All
Language
English

Resources and Publications

Educational Materials (1)