Thiamet G

Inhibits O-GlcNAcase

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Thiamet G

Inhibits O-GlcNAcase

From: 194 USD

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10 mg

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Inhibits O-GlcNAcase

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Overview

Thiamet G selectively inhibits O-GlcNAcase (Ki = 21 nM; Yuzwa et al.), an enzyme that removes O-linked β-N-acetylglucosamine (O-GlcNAc) from proteins; this inhibition of O-GlcNAcase blocks phosphorylation of the tau protein in vivo (Gong & Iqbal). Pathological hyperphosphorylation of the tau protein can aggregate and induce the formation of neurofibrillary tangles, which is a hallmark of Alzheimer’s disease (Gong & Iqbal; Yuzwa et al.). Thiamet G is blood-brain barrier permeable and can be used to study the function of O-GlcNAc in the vertebrate brain (Yuzwa et al.).

DISEASE MODELING
· Decreases phosphorylation of tau in rats (Yuzwa et al.).

Disease Modeling, Neuroscience

1009816-48-1

C9H16N2O4S

248.3 g/mol

≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

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Lot #

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Document Type

Product Information Sheet

Product Name

Thiamet G

Catalog #

100-0883

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Thiamet G

Catalog #

100-0883

Lot #

All

Language

English

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Thiamet G

Inhibits O-GlcNAcase

Thiamet G

Inhibits O-GlcNAcase

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Overview

Protocols and Documentation

Resources and Publications

Educational Materials (3)

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