Tauroursodeoxycholic Acid (Sodium Salt)

PI3K/AKT pathway inhibitor; Inhibits apoptosis

Tauroursodeoxycholic Acid (Sodium Salt)

PI3K/AKT pathway inhibitor; Inhibits apoptosis

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PI3K/AKT pathway inhibitor; Inhibits apoptosis
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Overview

Tauroursodeoxycholic acid is an endogenous hydrophilic bile and exhibits both anti-apoptotic and neuroprotective properties (Keene et al.; Yoon et al.). It protects against cell death by attenuating endoplasmic reticulum stress, inhibiting caspase activation and the production of oxygen radicals, and modulating the unfolded protein response (Vang et al.; Yoon et al.).

DISEASE MODELING
· Decreases both striatal atrophy and apoptosis in a mouse model of Huntington’s disease (Keene et al.).
· Blocks apoptotic events such as Bax translocation to mitochondrial membrane, cytochrome c release, caspase activation, and nuclear fragmentation (Vang et al.).
Alternative Names
Sodium tauroursodeoxycholate
Area of Interest
Disease Modeling, Neuroscience
CAS Number
14605-22-2
Chemical Formula
C26H44NO6SNa
Molecular Weight
521.7 g/mol
Purity
≥ 98%
Pathway
PI3K/AKT

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0884
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0884
Lot #
All
Language
English