Sirtinol

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

Sirtinol

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

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Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2
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Overview

Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC₅₀ = 68 μM; Grozinger et al.), human SIRT1 (IC₅₀ = 131 μM; Schuetz et al.), and SIRT2 (IC₅₀ = 38 μM; Grozinger et al.). It does not inhibit human HDAC1 activity (Grozinger et al.). Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.).

IMMUNOLOGY
· Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.).

CANCER RESEARCH
· Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.).
· Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.).
Alternative Names
Sir Two Inhibitor Naphthol
Cell Type
Cancer Cells and Cell Lines, Endothelial Cells, Leukemia/Lymphoma Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Area of Interest
Cancer, Immunology
CAS Number
410536-97-9
Chemical Formula
C₂₆H₂₂N₂O₂
Molecular Weight
394.5 g/mol
Purity
≥ 98%
Pathway
Epigenetic
Target
HDAC

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Sirtinol
Catalog #
73824
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Sirtinol
Catalog #
73824
Lot #
All
Language
English

Resources and Publications

Educational Materials (1)