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Sirtinol

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

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Sirtinol

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

10 mg
Catalog #73824
160 USD

Overview

Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC₅₀ = 68 μM; Grozinger et al.), human SIRT1 (IC₅₀ = 131 μM; Schuetz et al.), and SIRT2 (IC₅₀ = 38 μM; Grozinger et al.). It does not inhibit human HDAC1 activity (Grozinger et al.). Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.).

IMMUNOLOGY
· Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.).

CANCER RESEARCH
· Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.).
· Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.).
Alternative Names:
Sir Two Inhibitor Naphthol
CAS Number:
410536-97-9
Chemical Formula:
C₂₆H₂₂N₂O₂
Molecular Weight:
394.5 g/mol
Purity:
≥ 98%
Pathway:
Epigenetic
Target:
HDAC

Scientific Resources

Product Documentation

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(1)
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.