SCR7

NHEJ pathway inhibitor; inhibits DNA ligase IV

SCR7

NHEJ pathway inhibitor; inhibits DNA ligase IV

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NHEJ pathway inhibitor; inhibits DNA ligase IV
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Overview

SCR7 is an inhibitor of DNA ligase IV, which is responsible for the repair of DNA double-strand
breaks via the non-homologous end joining (NHEJ) repair pathway (Srivastava et al.). Due to its reported success in impeding cancer cell growth and potential impact on future cancer therapeutics, SCR7 has been closely studied in many recent publications (Hosoya & Miyagawa; John et al.).


GENOME EDITING
·Inhibits NHEJ-dependent DNA repair; this inhibition is reported to enhance precise homology-directed repair (HDR)-dependent CRISPR-Cas9 genome editing (Chu et al.; Maruyama et al.; Pinder et al.). However, these effects are cell type-specific and context-dependent (Song et al.; Xie et al.; Yang et al.; Zhang et al.).

CANCER RESEARCH
·Activates apoptosis of cancer cells by inhibiting DNA ligase IV to increase the efficacy of DNA double-strand break-inducing therapy (chemo- or radio-therapy) (Srivastava et al.).
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Genome Editing
Area of Interest
Cancer, Stem Cell Biology
CAS Number
1533426-72-0
Chemical Formula
C₁₈H₁₄N₄OS
Purity
≥ 95%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
SCR7
Catalog #
74104, 74102
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SCR7
Catalog #
74104, 74102
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages
Workflow Stages for Genome Editing