NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
From: 97 USD

Overview

NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. It is highly selective for DNA-PK, with an IC₅₀ of 14 nM (Leahy et al.).

GENOME EDITING
·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).

CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).
Alternative Names:
KU57788
CAS Number:
503468-95-9
Chemical Formula:
C₂₅H₁₉NO₃S
Molecular Weight:
413.5 g/mol
Purity:
≥ 98%

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.