KU0060648

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
From: 242 USD

Overview

KU0060648 is an ATP-competitive and highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), with IC₅₀ values of 19 nM in MCF7 human breast cancer cells and 170 nM in SW620 human colon cancer cells. KU0060648 also inhibits phosphoinositide 3-kinase (PI3K) with IC₅₀ values of 39 nM in MCF7 cells and > 10 µM in SW620 cells, which suggests a cell-dependent mechanism (Munck et al.).


GENOME EDITING
· Reduces the frequency of non-homologous end joining (NHEJ) and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).


CANCER RESEARCH
· Inhibits tumor growth and sensitizes human cancer cells to DNA double-strand-break (DSB)-inducing therapies (chemo- or radio-therapy) by inhibiting both DNA-PK and PI3K and preventing the execution of DSB repair (Chen et al.; Dietlein et al.; Munck et al.).
Alternative Names:
Not applicable
CAS Number:
881375-00-4
Chemical Formula:
C₃₃H₃₄N₄O₄S
Molecular Weight:
582.7 g/mol
Purity:
≥ 98%
Pathway:
PI3K/AKT

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.