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Clozapine N-Oxide

Activates DREADDs

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Clozapine N-Oxide

Activates DREADDs

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Overview

Clozapine N-Oxide is an inactive metabolite of clozapine and an activator of designer receptors exclusively activated by designer drugs (DREADDs; Manvich et al.). In mice, clozapine-N-oxide is converted back to the parent compound clozapine (Manvich et al.). Clozapine-N-oxide can activate G protein-coupled receptor activities that govern behavior, perceptions, and motor functions (Manvich et al.; Martinez et al.; Urban & Roth). Clozapine is administered as an antipsychotic and has shown efficacy in reducing cognitive and psychiatric symptoms in Parkinson’s patients (Stinton et al.).

DISEASE MODELING
· Lowers striatal glutamate level in rats (Bærentzen et al.).
· Elevates glutamate level in nucleus accumbens core in mice (Scofield et al.).
Alternative Names
CNO
Area of Interest
Disease Modeling, Neuroscience
CAS Number
34233-69-7
Chemical Formula
C18H19ClN4O
Molecular Weight
342.8 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Clozapine N-Oxide
Catalog #
100-0881
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Clozapine N-Oxide
Catalog #
100-0881
Lot #
All
Language
English

Resources and Publications

Educational Materials (3)

STEMCELL Neural Product Portfolio
Brochure
STEMCELL Neural Product Portfolio
hPSC-Derived Neural Cell Research
Brochure
hPSC-Derived Neural Cell Research
Neural Supplements For High-Quality Neural Cell Cultures
Brochure
Neural Supplements For High-Quality Neural Cell Cultures

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