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Celastrol

Inhibits topoisomerase II

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Celastrol

Inhibits topoisomerase II

From: 173 USD
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Inhibits topoisomerase II
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Overview

Celastrol is a topoisomerase II inhibitor (IC50 = 7.41 μM) with neuroprotective and anti-inflammatory properties (Allison et al.; Lin et al.; Nagase et al.; Sethi et al.). It improves memory, learning, and psychomotor activity performance when administered in rats and may have therapeutic potential for treating neurodegenerative disorders such as Alzheimer's disease (Allison et al.). In addition, celastrol suppresses TNF-α-induced NF-κB activation and increases TNF-induced apoptosis in chronic myelogenous leukemia cells (Sethi et al.).


IMMUNOLOGY
· Induces apoptosis in human leukemia cells (Nagase et al.).
DISEASE MODELING
·Activates mitophagy and inhibits dopaminergic neuronal apoptosis in mice (Lin et al.).
Cell Type
Leukemia/Lymphoma Cells, Neurons
Area of Interest
Disease Modeling, Immunology, Neuroscience
CAS Number
34157-83-0
Chemical Formula
C29H38O4
Molecular Weight
450.6 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Celastrol
Catalog #
100-0880
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Celastrol
Catalog #
100-0880
Lot #
All
Language
English

Resources and Publications

Educational Materials (4)

Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
STEMCELL Neural Product Portfolio
Brochure
STEMCELL Neural Product Portfolio
hPSC-Derived Neural Cell Research
Brochure
hPSC-Derived Neural Cell Research
Neural Supplements For High-Quality Neural Cell Cultures
Brochure
Neural Supplements For High-Quality Neural Cell Cultures

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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