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ABT-888 (Dihydrochloride)

PARP1 and PARP2 inhibitor

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ABT-888 (Dihydrochloride)

PARP1 and PARP2 inhibitor

From: 167 USD
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PARP1 and PARP2 inhibitor
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Overview

Inhibit cancer cell growth by inhibiting poly ADP ribose polymerase (PARP) with ABT-888 (Dihydrochloride). With a high affinity for both PARP1 and PARP2 (IC50 = 5.2 and 2.9 nM), ABT-888 is inactive against sirtuin 2 (Donawho et al.). ABT-888 inhibits PARPs and prevents them from repairing DNA breaks during DNA replication, which leads to DNA damage and apoptosis (Javle & Curtin).

ABT-888 has been used for:

CANCER RESEARCH
· Inhibits the growth of Capan1 cells with BRCA 2 mutations (Cincinelli et al.).
· Inhibits colony growth of PC-3 tumors, though no effect in DU-145 tumors has been found (Barreto-Andrade et al.).
Alternative Names
Veliparib
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
912445-05-7
Chemical Formula
C13H16N4O • 2HCl
Molecular Weight
317.2 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
ABT-888 (Dihydrochloride)
Catalog #
100-1170
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
ABT-888 (Dihydrochloride)
Catalog #
100-1170
Lot #
All
Language
English

Resources and Publications

Educational Materials (3)

Small Molecules for Your Research
Brochure
Small Molecules for Your Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Small Molecules
Mini Review
Small Molecules

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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