Small Molecules

  • Featured CHIR99021

    CHIR99021

    WNT pathway activator; Inhibits GSK3
  • Featured Y-27632 (Dihydrochloride)

    Y-27632

    RHO/ROCK pathway inhibitor; Inhibits ROCK1 and ROCK2
  • Sirtinol

    Sirtinol

    Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2
  • (Z)-4-Hydroxytamoxifen

    (Z)-4-Hydroxytamoxifen

    Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
  • KU0060648

    KU0060648

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • Nocodazole

    Nocodazole

    Microtubule polymerization inhibitor; Inhibits beta-tubulin
  • NU7441

    NU7441

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • RS-1

    RS-1

    HDR pathway enhancer; Enhances RAD51
  • SCR7

    SCR7

    NHEJ pathway inhibitor; inhibits DNA ligase IV
  • BSI-201

    BSI-201

    Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells
  • CGP77675

    CGP77675

    Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK
  • Hydrocortisone

    Hydrocortisone

    Enhances proliferation and differentiation of endothelial, epithelial, mesenchymal, and oligodendrocyte cells
  • FK506

    FK506

    Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
  • LY2228820

    LY2228820

    p38 MAP kinase (MAPK) inhibitor
  • NU7026

    NU7026

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • MLN4924

    MLN4924

    Inhibits NEDD8-activating enzyme
  • 4-Octyl Itaconate

    4-Octyl Itaconate

    Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
  • SMER28

    SMER28

    Enhances mammalian autophagy
  • 3-Methyladenine

    3-Methyladenine

    PI3K/AKT pathway inhibitor
  • Delphinidin

    Delphinidin

    Inhibits EGFR and VEGFR
  • Bafilomycin A1

    Bafilomycin A1

    Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
  • 1-Azakenpaullone

    1-Azakenpaullone

    Inhibits glycogen synthase kinase 3β (GSK3β)
  • Tamoxifen

    Tamoxifen

    Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
  • UM729

    UM729

    Pyrimido-indole derivative that enhances HSC self-renewal in vitro
  • SB431542 (Hydrate)

    SB431542

    Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK4, ALK5, and ALK7
  • Eltrombopag

    Eltrombopag

    Thrombopoietin receptor agonist
  • (Z)-Guggulsterone

    (Z)-Guggulsterone

    Retinoic acid receptor (RAR) pathway inhibitor; Inhibits farnesoid X receptor (FXR)
  • Torin 2

    Torin 2

    mTOR pathway inhibitor; Inhibits mTOR
  • GSK621

    GSK621

    AMPK agonist
  • Perhexiline Maleate

    Perhexiline Maleate

    Carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor
  • Vps34-IN1

    Vps34-IN1

    Vps34 inhibitor
  • Verteporfin

    Verteporfin

    YAP1 inhibitor
  • SBI-0206965

    SBI-0206965

    ULK1 and ULK2 kinase inhibitor
  • FK-866

    FK-866

    Nicotinamide phosphoribosyltransferase inhibitor
  • Oleuropein

    Oleuropein

    PPARγ antagonist
  • ME0328

    ME0328

    PARP-3 inhibitor
  • Dorsomorphin

    Dorsomorphin

    BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK
  • Quercetin (Hydrate)

    Quercetin

    mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases
  • New Minocycline (Hydrochloride Hydrate)

    Minocycline

    Antibiotic with anti-inflammatory and neuroprotective properties
  • New HPI-1 (Hydrate)

    HPI-1

    Hedgehog pathway inhibitor
  • AICAR

    AICAR

    AMPK activator
  • New (2R)-Octyl-α-hydroxyglutarate

    (2R)-Octyl-α-hydroxyglutarate

    Inhibits α-ketoglutarate-dependent dioxygenases
  • New Uridine

    Uridine

    Nucleoside for RNA synthesis
  • New SANT-1

    SANT-1

    Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)
  • New Erastin

    Erastin

    Cystine transporter inhibitor; Induces ferroptosis
  • New 2-NBDG

    2-NBDG

    Fluorescent glucose analog
  • New 3,3',5-Triiodo-L-thyronine (Sodium Salt Hydrate)

    3,3',5-Triiodo-L-thyronine (Sodium Salt Hydrate)

    TRα and TRβ agonist
  • New Camostat (Mesylate)

    Camostat

    Inhibits transmembrane serine protease (TMPRSS2)