Small Molecules

  • Featured CHIR99021

    CHIR99021

    WNT pathway activator; Inhibits GSK3
  • Featured Dorsomorphin

    Dorsomorphin

    BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK
  • Featured Y-27632 (Dihydrochloride)

    Y-27632

    RHO/ROCK pathway inhibitor; Inhibits ROCK1 and ROCK2
  • Featured SB431542

    SB431542

    Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK4, ALK5, and ALK7
  • Featured UM729

    UM729

    Pyrimido-indole derivative that enhances HSC self-renewal in vitro
  • AICAR

    AICAR

    AMPK activator
  • Sirtinol

    Sirtinol

    Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2
  • (Z)-4-Hydroxytamoxifen

    (Z)-4-Hydroxytamoxifen

    Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
  • KU0060648

    KU0060648

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • Nocodazole

    Nocodazole

    Microtubule polymerization inhibitor; Inhibits beta-tubulin
  • NU7441

    NU7441

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • RS-1

    RS-1

    HDR pathway enhancer; Enhances RAD51
  • SCR7

    SCR7

    NHEJ pathway inhibitor; inhibits DNA ligase IV
  • Minocycline

    Minocycline

    Antibiotic with anti-inflammatory and neuroprotective properties
  • BSI-201

    BSI-201

    Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells
  • CGP77675

    CGP77675

    Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK
  • Hydrocortisone

    Hydrocortisone

    Enhances proliferation and differentiation of endothelial, epithelial, mesenchymal, and oligodendrocyte cells
  • FK506

    FK506

    Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
  • LY2228820

    LY2228820

    p38 MAP kinase (MAPK) inhibitor
  • NU7026

    NU7026

    NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
  • MLN4924

    MLN4924

    Inhibits NEDD8-activating enzyme
  • 4-Octyl Itaconate

    4-Octyl Itaconate

    Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
  • SMER28

    SMER28

    Enhances mammalian autophagy
  • Hydroxychloroquine

    Hydroxychloroquine

    Inhibits autophagy and heme polymerase
  • 3-Methyladenine

    3-Methyladenine

    PI3K/AKT pathway inhibitor
  • Delphinidin

    Delphinidin

    Inhibits EGFR and VEGFR
  • Bafilomycin A1

    Bafilomycin A1

    Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
  • 1-Azakenpaullone

    1-Azakenpaullone

    Inhibits glycogen synthase kinase 3β (GSK3β)
  • Tamoxifen

    Tamoxifen

    Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
  • (+)-Bay K8644

    (+)-Bay K8644

    L-type calcium channel inhibitor
  • (-)-Blebbistatin

    (-)-Blebbistatin

    Non-muscle myosin II (NM II) ATPase inhibitor
  • (-)-Epigallocatechin Gallate

    (-)-Epigallocatechin Gallate

    Antioxidant and epigenetic modifier; Inhibits DNA methyltransferases (DNMTs)
  • (-)-Indolactam V

    (-)-Indolactam V

    Protein kinase C (PKC) activator
  • (S)-MG132

    (S)-MG132

    Ubiquitin-proteasome inhibitor; NF-kB pathway inhibitor; IκB activator
  • Flurbiprofen

    (±)-Flurbiprofen

    PI3K/AKT pathway inhibitor; Inhibits COX-1 and COX-2
  • (±)-Nutlin-3

    (±)-Nutlin-3

    p53 pathway activator; Inhibits MDM2