iCell® Retinal Pigment Epithelial Cells, 01279

Retinal Pigment Epithelial Cells derived from human iPS cells, frozen

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From: 385 USD

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Retinal Pigment Epithelial Cells derived from human iPS cells, frozen
From: 385 USD

Overview

Ocular diseases such as age-related macular degeneration (AMD) and diabetic retinopathy are a result of progressive deterioration of eye tissue leading to loss of vision. The retinal pigment epithelium consists of the pigmented cell layer just outside the neurosensory retina that nourishes the visual photoreceptor cells. Its functions include phagocytosis of photo-damaged photoreceptor outer segments, secretion of essential factors and signaling molecules to maintain retinal homeostasis, and absorption of scattered light and protection against photo-oxidation. iCell® Retinal Pigment Epithelial Cells provide researchers with a human cell model system for understanding basic ocular biology and to develop treatments for ocular diseases.

iCell® Retinal Pigment Epithelial Cells are a highly pure population of research-grade retinal pigment epithelial (RPE) cells derived from human induced pluripotent stem (iPS) cells, available in commercial quantities, with the following features:

• Lineage-committed at cryopreservation, the cells mature within 1 month in vitro:
- ≥ 90% (PMEL17, TYRP1) pure population for immature RPE markers at thaw
- 80% (BEST1, CRALBP) pure population for more mature RPE markers at 4 weeks post-thaw

• Pattern of marker-expression is characteristic of mature RPE cells

• Expected morphology advances over time

• Robust functionality exhibited within weeks post-thaw:
- Increasing trans-epithelial electrical resistance (TEER) over time
- Phagocytotic activity

Certain products are only available in select territories. Please contact Product & Scientific Support at techsupport@stemcell.com for further information.
Subtype:
Frozen
Cell Type:
Epithelial Cells, PSC-Derived
Species:
Human
Cell and Tissue Source:
Pluripotent Stem Cells
Brand:
iCell
Donor Status:
Normal

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.