iCell® Endothelial Cells Kit, 11713

Endothelial cells derived from human iPS cells, frozen

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iCell® Endothelial Cells Kit, 11713

Endothelial cells derived from human iPS cells, frozen

1 x 106 cells
Catalog #R1112
995 USD

Overview

Endothelial cells are highly dynamic cells that form the inner lining of blood vessels. In addition to their structural role, endothelial cells regulate the passage of substances between the bloodstream and surrounding tissue. They also secrete mediators that influence vascular hemodynamics, inflammation, cell trafficking, and the remodeling and formation of new blood vessels. Endothelial cell dysfunction is associated with a variety of diseases including atherosclerosis, coronary artery disease, hypertension, and inflammatory disorders.

Derived from human iPS cells, CDI’s iCell® Endothelial Cells provide a reliable, reproducible, and physiologically relevant source of cells for vascular disease modeling, drug screening, and vascular tissue engineering applications. Benefits include:
• > 90% CD31+/CD105+ populations across lots and multiple passages
• VEGF-mediated proliferation, sprouting, migration, and invasion
• TNFα-mediated upregulation of adhesion molecules
• Thrombin-sensitive barrier function
• Acetylated LDL uptake
• Shear stress-induced alignment
• 2D and 3D capillary-like network formation

Broad Function and Application

Assayed as a pure culture or in co-culture with other differentiated cell types to recapitulate native tissue architecture, iCell® Endothelial Cells enable a variety of novel applications:
• Vascular tissue engineering: Decellularized organ (e.g. kidney) scaffold approaches
• Vascular tissue engineering: Natural matrices and bioengineering scaffolds (e.g. microfluidic device and bioreactor system cultures)
• Angiogenesis and wound healing: Providing relevant biology for the study of blood vessel formation and remodeling relevant to cancer, chronic inflammatory, and degenerative diseases
• Infectious disease studies

Certain products are only available in select territories. Please contact your local Sales Representative or Product & Scientific Support at techsupport@stemcell.com for further information."
Components:
iCell® Endothelial Cells, 11713, 1 x 10^6 cells
iCell® Endothelial Cells Medium Supplement, 50 mL
Subtype:
Frozen
Cell Type:
Endothelial Cells, PSC-Derived
Species:
Human
Cell and Tissue Source:
Pluripotent Stem Cells
Brand:
iCell

Scientific Resources

Educational Materials

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.