Human Platelet Lysate, Pathogen-Reduced, GMP-Compliant

Growth factor-rich supplement for the expansion of cells in vitro

Human Platelet Lysate, Pathogen-Reduced, GMP-Compliant

Growth factor-rich supplement for the expansion of cells in vitro

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Growth factor-rich supplement for the expansion of cells in vitro
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Product Advantages


  • Minimize lot-to-lot variability with hPL pooled from over 100 donors

  • Reduce the risk of infection in your cultures from xenogeneic proteins or viruses by using a human-derived supplement

  • Avoid the use of heparin, with a high-quality, pathogen-reduced supplement

  • Confidently expand MSCs, T cells, and other cell types for use in clinical applications by using medium produced under relevant GMPs

Overview

Start experiments confidently with a reliable supply of ethically sourced, GMP-compliant, fibrinogen-depleted, and pathogen-reduced human platelet lysate (hPL) for the expansion of cells in vitro. An alternative to fetal bovine serum (FBS), this growth factor-rich cell culture supplement is derived from healthy donor human platelets, and multiple donor units are pooled during manufacturing to minimize lot-to-lot variability. Heparin is not added during the manufacturing process and is not required for use of this product. An electron beam (e-beam) irradiation step is included in the manufacturing process for pathogen reduction.

hPL is sourced from U.S. Food and Drug Administration (FDA)-registered, AABB-certified blood banks in the United States.

Consent is obtained from volunteers participating in a donor collection program that is reviewed and/or approved by either an Institutional Review Board (IRB), the U.S. FDA, U.S. Department of Health and Human Services, and/or an equivalent regulatory authority.

Certain products are only available in select territories. Please contact your sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.

Browse Frequently Asked Questions (FAQs) on Primary Cells.


Subtype
Frozen
Cell Type
Platelets
Species
Human
Cell and Tissue Source
Peripheral Blood
Application
Cell Culture, Expansion
Area of Interest
Cell Therapy Development
Donor Status
Normal

Data Figures

Table 1. Properties of Human Platelet Lysate Cell Culture Supplements for Ex Vivo Cell Expansion

Properties of Human Platelet Lysate Cell Culture Supplements for Ex Vivo Cell Expansion

The human platelet lysate (hPL) product recommended for the expansion of cells ex vivo varies depending on the starting cell type, intended application, and experimental compliance required. (1) Fibrinogen has not been depleted, therefore addition of an anticoagulant (e.g. Heparin Solution; Catalog #07980) is required to inhibit coagulation. (2) Fibrinogen has been depleted during manufacturing. Pharmaceutical-grade heparin derived from porcine intestine is used in the manufacturing process and the concentration of heparin in final product is ≤ 2 IU/mL. (3) Fibrinogen has been depleted during manufacturing; heparin is not added during the manufacturing process and addition of anticoagulants is not required for use of this product.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
200-0720, 200-0721
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.