Rat Recombinant EGF

Epidermal growth factor

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Epidermal growth factor
From: 80 USD

Overview

Epidermal growth factor (EGF) is the founding member of the EGF family of proteins and is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter & Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds & Weiss).
Alternative Names:
Beta-urogastrone, Epidermal growth factor, HOMG4, Pro-epidermal growth factor, Pro-epidermal growth factor precursor, URG, Urogastrone
Cell Type:
Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells; Neural Stem and Progenitor Cells; Neurons; Prostate Cells; Brain Tumor Stem Cells; Mesoderm, PSC-Derived; Endoderm, PSC-Derived; Pluripotent Stem Cells; Neural Cells, PSC-Derived
Species:
Rat
Area of Interest:
Stem Cell Biology; Epithelial Cell Biology; Neuroscience; Cancer Research
Molecular Weight:
6.3 kDa
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Rat Recombinant EGF was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.08 ng/mL. (B) 2 μg of Rat Recombinant EGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.