Mouse Recombinant IL-33

Interleukin 33

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Interleukin 33
From: 201 USD

Overview

Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).
Alternative Names:
IL-1F11, Interleukin-33
Cell Type:
Monocytes; T Cells, Other Subsets
Species:
Mouse
Area of Interest:
Immunology
Molecular Weight:
17.5 kDa
Purity:
> 95%

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(3)

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-33 was tested by its ability to promote the proliferation of D10S cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.47 ng/mL.
(B) 5 μg of Mouse Recombinant IL-33 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-33 has a predicted molecular mass of 17.5 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.