Mouse Recombinant IL-22

Interleukin 22

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Interleukin 22
From: 202 USD

Overview

Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).
Alternative Names:
IL-TIF, Interleukin-22
Cell Type:
Intestinal Cells; Hepatic Cells; Airway Cells; Keratinocytes; T Cells; T Cells, CD4+; T Cells, CD8+
Species:
Mouse
Area of Interest:
Immunology; Epithelial Cell Biology
Molecular Weight:
16.8 kDa
Purity:
≥ 95%

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(3)

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-22 was tested by its ability to produce IL-10 in COLO 205 cells. IL-10 secretion was measured after 4 days of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which IL-10 production is at 50% of maximum. The EDC50 in the above example is 0.15 - 0.23 ng/mL.
(B) 1 μg of Mouse Recombinant L-22 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-22 has a predicted molecular mass of 16.8 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.