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Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes Interleukin 17B through Interleukin 17F. It is a potent proinflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-kB, MAPK, and C/EBP pathways (Gaffen). IL-17A receptor is expressed on a variety of cell types, including hematopoietic cell compartments. IL-17A is produced by T helper 17 cells, CD8+ T cells, γδ T cells, natural killer T cells, B cells, neutrophils, innate lymphoid cells and mesenchymal stromal cells (MSCs; Zenobia & Hajishengallis; Mojsilovic et al.). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of colony-forming units-fibroblast derived from bone marrow, as well as the proliferation of bone marrow-derived MSCs. IL-17A suppresses osteogenic differentiation and bone formation of bone marrow-derived MSCs. The action of IL-17A on hematopoiesis is deeply reliant on the microenvironment and the induction of other regulators. In healthy mouse bone marrow, IL-17A stimulates myeloid and early stage erythroid progenitor cells but inhibits late stage erythroid progenitor cells (Mojsilovic et al.).
Subtype
Cytokines
Cell Type
B Cells, Lymphocytes, T Cells, T Cells, CD4+, T Cells, CD8+
(A) The biological activity of Mouse Recombinant IL-17A was tested by its ability to produce IL-6 in NIH 3T3 cells. Production of mouse
IL6
was measured after 48 hours of culture. The EC50 is defined as the effective concentration of the growth factor at which IL-6
production is at 50% of maximum. The EC50 in the above example is 0.3 - 1.5 ng/mL.
(B) 1 ug of Mouse Recombinant IL-17A was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized
by Coomassie Blue staining. Mouse Recombinant IL-17A is a homodimer of 15.1 kDa subunits with a predicted total molecular mass of
30.2 kDa.
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