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Mouse Recombinant IL-1 alpha

Interleukin 1 alpha

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From: 369 USD

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Interleukin 1 alpha
From: 369 USD

Overview

Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes have high levels of intracellular IL-1α precursor, which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al.; Cohen et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
Alternative Names:
BAF, B-cell-activating factor, Epidermal cell-derived thymocyte-activating factor, ETAF, FAF, Fibroblast-activating factor, IL-1F1, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor
Cell Type:
Angiogenic Cells; B Cells; Endothelial Cells; Epithelial Cells; Neural Stem and Progenitor Cells; Macrophages; Monocytes
Area of Interest:
Angiogenic Cell Research; Endothelial Cell Biology; Epithelial Cell Biology; Immunology
Molecular Weight:
18.1 kDa
Purity:
≥ 95%

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Educational Materials

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Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-1 alpha was tested by its ability to promote the proliferation of D10.G4.1 cells. Cell proliferation was measured after 72 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00581 ng/mL. (B) 1 μg of Mouse Recombinant IL-1 alpha was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.