Human Recombinant VEGF-121

Vascular endothelial growth factor

More Views

From: 197 USD

Options

* Required Fields

Catalog # (Select a product)
Vascular endothelial growth factor
From: 197 USD

Overview

Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.).
Alternative Names:
MGC70609, MVCD-1, Vascular endothelial growth factor, Vascular endothelial growth factor 2, Vascular endothelial growth factor A, Vascular permeability factor, VEGF­A, VPF
Cell Type:
Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells; Neural Stem and Progenitor Cells; Angiogenic Cells; Mesoderm, PSC-Derived; Pluripotent Stem Cells; Endothelial Cells
Species:
Human
Area of Interest:
Stem Cell Biology; Endothelial Cell Biology; Neuroscience; Angiogenic Cell Research
Molecular Weight:
14.2 kDa monomer, 28.4 kDa dimer
Purity:
≥ 95%

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant VEGF-121 was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 4.02 ng/mL. (B) 1 μg of Human Recombinant VEGF-121 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.