Human Recombinant TNF-receptor 1

Tumor necrosis factor receptor 1

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Tumor necrosis factor receptor 1
From: 197 USD

Overview

Tumor necrosis factor receptor type 1 (TNFR1) is a member of the TNF receptor superfamily and is activated upon binding to TNF-α. TNFR1 activates NF-kB and MAPK pathways, which results in inflammation, apoptosis, and inhibition of tumorigenesis and viral replication. TNFR1 is essential for transducing TNF signals during organogenesis and surviving infections caused by intracellular bacteria (Hehlgans & Pfeffer). Soluble TNFR1 is released into the bloodstream to bind circulating TNF-α and suppress inflammation. Mutations in TNFR1 result in TNFR-associated periodic syndrome that manifests with inflammatory episodes (Turner et al.).
Alternative Names:
CD120a, TNFAR, TNFR55, TNFRSF1A
Cell Type:
Granulocytes and Subsets; Monocytes; T Cells
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
18.3 kDa
Purity:
≥ 95%

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(1)

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Data and Publications

Data

(A) The biological activity of Human Recombinant TNF-receptor 1 was tested by its ability to neutralize human TNF-alpha induced cytolysis of L929 cells. Cell viability was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell viability is at 50% of maximum. The EC50 in the above example is 0.01 μg/mL. (B) 1 μg of Human Recombinant TNF-receptor 1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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