Human Recombinant TNF-beta

Tumor necrosis factor beta

Human Recombinant TNF-beta

Tumor necrosis factor beta

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Tumor necrosis factor beta
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Overview

Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).
Subtype
Cytokines
Cell Type
T Cells
Species
Human
Area of Interest
Immunology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78125.1, 78125
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78125.1, 78125
Lot #
All
Language
English

Applications

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Resources and Publications

Educational Materials (1)