Human Recombinant TNF-beta

Tumor necrosis factor beta
Catalog #
78125_C
Tumor necrosis factor beta
From: 169 USD

Overview

Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).
Subtype
Cytokines
Alternative Names
LT-α, Lymphotoxin-alpha, TNF-beta, TNFSF1, Tumor necrosis factor-β
Cell Type
T Cells
Species
Human
Area of Interest
Immunology
Molecular Weight
18.8 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant TNF-beta
Catalog #
78125
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant TNF-beta
Catalog #
78125
Lot #
All
Language
English

Educational Materials(1)

Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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