Human Recombinant TNF-beta

Tumor necrosis factor beta

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Tumor necrosis factor beta
From: 161 USD

Overview

Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).
Alternative Names:
LT-α, Lymphotoxin-alpha, TNF-beta, TNFSF1, Tumor necrosis factor-β
Cell Type:
T Cells
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
18.8 kDa
Purity:
≥ 95%

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(1)

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Data and Publications

Data

(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.