Human Recombinant TGF-beta 2

Transforming growth factor beta 2

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Transforming growth factor beta 2
From: 191 USD

Overview

Transforming growth factor (TGF) beta 2 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. Similar to TGF-β1 & -β3, TGF-β2 signals via serine-threonine kinase type I and II receptors and activates signal transduction via SMAD family proteins, regulating a variety of functions such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism (de Caestecker; Massague; Zuniga et al.). TGF-β2 is important in many developmental processes; for example, mice with TGF-β2 deletions show defects in the development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems (Dunker & Kreiglstein).
Alternative Names:
BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, TGF-beta-2, TGFB2, Transforming growth factor beta-2
Cell Type:
Mesenchymal Stem and Progenitor Cells; Mesenchymal Cells, PSC-Derived; Airway Cells
Species:
Human
Area of Interest:
Respiratory Research; Stem Cell Biology
Molecular Weight:
12.7 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant TGF-beta 2 was tested by its ability to promote the proliferation of mouse HT-2 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL. (B) 5 μg of Human Recombinant TGF-beta 2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant TGF-beta 2 has a predicted molecular mass of 12.7 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.