Human Recombinant PF-4 (CXCL4)

Platelet factor 4

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Platelet factor 4
From: 102 USD

Overview

Platelet factor 4 (PF-4), or CXCL4, is a member of the CXC chemokine family. It is produced by megakaryocytes, platelets, and cultured microglial cells (Kasper & Petersen; Wang & Huang). Although its receptors have not been fully characterized, PF-4 appears to affect p38/MAPK, PI3K/AKT, ERK, and JNK/c-Jun signaling pathways. PF-4 inhibits the development and maturation of megakaryocytes, and supports survival of hematopoietic stem and progenitor cells (Kasper & Petersen). PF-4 inhibits angiogenesis by suppressing endothelial cell proliferation and migration. It promotes inflammatory response through activation of granulocytes, T cells, and monocytes, which results in the release of oxygen radicals and cytokines, and induces phagocytosis. PF-4 stimulates NK cell migration, inhibits platelet coagulation, and together with TNF, PF-4 causes neutrophile degranulation (Kasper & Petersen; Wang & Huang).
Alternative Names:
CXCL4, Ironplact, Oncostatin A, Platelet factor-4, SCYB4
Cell Type:
Hematopoietic Stem and Progenitor Cells; Monocytes
Species:
Human
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
7.8 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant PF-4 (CXCL4) was tested by its ability to inhibit human FGF-basic-dependent proliferation of mouse NR6R 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is less than 10 μg/mL. (B) 5 μg of Human Recombinant PF-4 (CXCL4) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant PF-4 (CXCL4) has a predicted molecular mass of 7.8 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.