Human Recombinant NT-4

Neurotrophin 4

More Views

From: 202 USD

Options

* Required Fields

Catalog # (Select a product)
Neurotrophin 4
From: 202 USD

Overview

Neurotrophin-4 (NT-4) is a member of the nerve growth factor family which includes neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF), all of which promote the differentiation, growth, and survival of peripheral and central nervous system neurons (Eide et al.). NT-4 binds and activates tropomyosin receptor kinase B (TrkB) at the cell surface; in doing so, it acts as a survival factor for certain populations of sensory neurons (Berkemeier et al.; Skaper). It has been shown that NT-4, together with BDNF, promotes neurite extension and maturation, as well as maintenance of differentiated cerebellar granule cells (Gao et al.).
Alternative Names:
GLC10, GLC1O, Neutrophic factor 4, Neutrophic factor 5, Neurotrophin-5, NT-4/5, NT-5, NTF4, NTF5
Cell Type:
Astrocytes; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons
Species:
Human
Area of Interest:
Neuroscience; Stem Cell Biology
Molecular Weight:
14.0 kDa monomer; 28.1 kDa dimer
Purity:
≥ 95%

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language

Educational Materials

(4)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant NT-4 was tested by its ability to promote the proliferation of C6 cells. Cell proliferation was measured after 7 days of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.6 μg/mL. (B) 1 μg of Human Recombinant NT-4 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant NT-4 is a homodimer of 14 kDa subunits with a predicted total molecular mass of 28.1 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.