Human Recombinant Myostatin

Myostatin

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Myostatin
From: 197 USD

Overview

Myostatin is a member of transforming growth factor beta (TGF-β) superfamily that signals by binding to activin type II receptor, resulting in the recruitment of either ALK3 or ALK4 coreceptor, and activation of SMAD2/3 (Kondás et al.). It is released by myocytes and inhibits muscle growth and ability to regenerate (Lee & Lee). Myostatin appears to affect the lipid catabolic metabolism of adipocytes and inhibits preadipocyte differentiation, as demonstrated in the 3T3-L1 cell line (Li et al.).
Alternative Names:
GDF-8, Growth differentiation factor 8, MSTN78
Cell Type:
Mesenchymal Stem and Progenitor Cells
Species:
Human
Area of Interest:
Stem Cell Biology
Molecular Weight:
12.4 kDa monomer, 24.8 kDa dimer
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant Myostatin was tested by its ability to inhibit proliferation of MPC-11 cells. Cell viability was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell viability is at 50% of maximum. The EC50 in the above example is 12 ng/mL. (B) 1 μg of Human Recombinant Myostatin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.