Human Recombinant MCP-2 (CCL8)

Monocyte chemoattractant protein 2

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Monocyte chemoattractant protein 2
From: 184 USD

Overview

Monocyte chemoattractant protein (MCP) 2, or CCL8, belongs to the MCP subgroup of the CC family of chemokines, which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 signals primarily through the CCR1 and CCR5 receptors to attract monocytes, activated NK cells, and CD4+ and CD8+ T cells (Romagnani). MCP-2 has also been shown to induce the release of histamine from basophils via the CCR2 receptor (Gangur & Oppenheim).
Alternative Names:
HC14, Monocyte chemoattractant protein-2, SCYA8
Cell Type:
NK Cells; Monocytes; T Cells, CD4+; T Cells, CD8+
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
8.9 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant MCP-2 (CCL8) was tested using CHO cells transfected with human CCR5. Calcium mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of CCL8 where calcium mobilization is at 50% of maximum. The EC50 in the example above is less than 0.5 μg/mL. (B) 2 μg of Human Recombinant MCP-2 (CCL8) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant MCP-2 (CCL8) has a predicted molecular mass of 8.9 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.