Human Recombinant MCP-1 (CCL2)

Monocyte chemotactic protein 1

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Monocyte chemotactic protein 1
From: 82 USD

Overview

Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran et al.). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani et al.). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing et al.; Deshmane et al.). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier et al.).
Alternative Names:
DIA, Differentiation-inducing factor, HILDA, Human interleukin in DA cells, Leukemia inhibitory factor, MCAF, Melanoma-derived LPL inhibitor, MLPLI, Monocyte chemoattractant protein 1
Cell Type:
Macrophages; Monocytes; Myeloid Cells; T Cells; NK Cells
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
8.7 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant MCP-1 was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 1 hour using a fluorometric assay method. Increase in migration over basal level was seen starting at 1 ng/mL. (B) 1 μg of Human Recombinant MCP-1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant MCP-1 has a predicted molecular mass of 8.7 kDa.

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