Human Recombinant IL-9

Interleukin 9

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Interleukin 9
From: 202 USD

Overview

Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops & Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami & Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).
Alternative Names:
Interleukin-9, Mast cell growth-enhancing activity, Mast cell growth factor, MCGF, MEA, p40 cytokine, TCGF-3, T-cell growth factor 3
Cell Type:
Airway Cells; T Cells; T Cells, CD4+; T Cells, Regulatory
Species:
Human
Area of Interest:
Epithelial Cell Biology; Immunology
Molecular Weight:
25 - 40 kDa
Purity:
≥ 95 %

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language
78085, 78085.1, 78085.2, 78085.3, 78085.4
All
78085, 78085.1, 78085.2, 78085.3, 78085.4
All

Educational Materials

(3)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-9 was tested by its ability to promote the proliferation of MO7e cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 1 ng/mL. (B) 2 μg of Human Recombinant IL-9 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-9 has a predicted molecular mass of 25 - 40 kDa.

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