Human Recombinant IGFBP-4

Insulin-like growth factor-binding protein 5

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Human Recombinant IGFBP-4

Insulin-like growth factor-binding protein 5

From: 174 USD

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Insulin-like growth factor-binding protein 5

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Overview

Insulin-like growth factor-binding protein 4 (IGFBP-4) inhibits the actions of IGF-I and IGF-II. The distribution of IGFBP-4 in tissues is dependent on its glycosylation state, however it preferentially targets connective tissue (Firth & Baxter; Qin et al.). IGFBP-4 is also produced in liver, adrenal glands, Leydig cells, developing embryos, spinal cord, and thymic cortex. IGFBP-4 inhibits WNT/β-catenin signaling, which downregulates prostate cancer proliferation (Zhu et al.). In vitro studies suggest that IGFBP-4 inhibits proliferation of neuroblastoma and glioma, while promoting bone loss in osteosarcoma and multiple myeloma (Durai et al.).

Cytokines, Growth Factors

Mesenchymal Stem and Progenitor Cells

Human

Stem Cell Biology

≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IGFBP-4 was tested by its ability to inhibit IGF-II induced proliferation of FDC-P1 cells.Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.05 μg/mL. (B) 5 μg of Human Recombinant IGFBP-4 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recmbinant IGFBP-4 has a predicted molecular mass of 26.8 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

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Document Type

Product Information Sheet

Product Name

Human Recombinant IGFBP-4

Catalog #

78164, 78164.1

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Human Recombinant IGFBP-4

Catalog #

78164, 78164.1

Lot #

All

Language

English

Resources and Publications

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Human Recombinant IGFBP-4

Insulin-like growth factor-binding protein 5

Human Recombinant IGFBP-4

Insulin-like growth factor-binding protein 5

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Overview

Data Figures

Protocols and Documentation

Resources and Publications

Educational Materials (6)

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