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Human Recombinant HBEGF

Heparin-binding EGF-like growth factor

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Human Recombinant HBEGF

Heparin-binding EGF-like growth factor

From: 86 USD
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Heparin-binding EGF-like growth factor
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Overview

Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi & Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto & Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi & Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto & Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.).
Subtype
Cytokines, Growth Factors
Cell Type
Fibroblasts, Keratinocytes, Smooth Muscle, T Cells, CD4+
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant HBEGF was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.75 ng/mL. (B) 2 μg of Human Recombinant HBEGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HBEGF has a predicted molecular mass of 9.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant HBEGF
Catalog #
78163, 78163.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant HBEGF
Catalog #
78163, 78163.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (5)

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Brochure
Reliable Antibodies for Your Research
Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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