Human Recombinant HBEGF, ACF

Heparin-binding EGF-like growth factor, animal component-free

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Heparin-binding EGF-like growth factor, animal component-free
From: 66 USD

Overview

Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi & Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto & Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi & Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto & Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.). This product is animal component-free.
Alternative Names:
Diptheria toxin receptor, DT-R, DTS, HB-EGF, Heparin-binding EGF-like growth factor, Heparin-binding epidermal growth factor, Heparin-binding epidermal growth factor-like growth factor, Proheparin-binding EGF-like growth factor
Cell Type:
Fibroblasts; Keratinocytes; Smooth Muscle; T Cells, CD4+
Species:
Human
Area of Interest:
Epithelial Cell Biology; Immunology
Molecular Weight:
9.9 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant HBEGF, ACF was tested by its ability to promote proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.167 ng/mL. (B) 1 μg of Human Recombinant HBEGF, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HBEGF, ACF has a predicted molecular mass of 9.9 kDa.

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.