Human Recombinant Epigen

Epigen
Catalog #
78120_C
Epigen
From: 152 USD

Overview

Epigen belongs to the family of epidermal growth factor (EGF) ligands. It is expressed in a variety of tissues, including hepatic, testicular, cardiac, pulmonary, and others. Upon binding to EGF receptor expressed on epithelial cells, epigen triggers mitosis (Schneider & Yarden). The strong mitogenic potential can be explained by the low-affinity binding to EGF receptor, which results in downregulation of receptor ubiquitination. Epigen is also expressed in adenocarcinomas, suggesting a role in oncogenesis (Kochupurakkal et al.).
Subtype
Cytokines
Alternative Names
EPG, EPGN, Epithelial mitogen
Cell Type
Epithelial Cells, Intestinal Cells, Mammary Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology
Molecular Weight
8.1 kDa
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant Epigen
Catalog #
78120, 78120.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant Epigen
Catalog #
78120, 78120.1
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant Epigen was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 1 μg/mL. (B) 2 μg of Human Recombinant Epigen was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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