Human Recombinant Cardiotrophin-1

Cardiotrophin 1
Catalog #
78160_C
Cardiotrophin 1
From: 185 USD

Overview

Cardiotrophin-1 is a member of the IL-6 (interleukin 6) cytokine family that includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). Cardiotrophin-1 is a pleiotropic cytokine with activity that overlaps with other IL-6 family members. Cardiotrophin-1 is expressed in various tissues including heart, skeletal muscle, liver, lung, kidney, ovary, colon, and prostate. It initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit (Pennica et al.; Robledo et al.). Binding of cardiotrophin-1 initiates signaling through the JAK/STAT, MEK/ERK, and AKT pathways. Cardiotrophin-1 has been shown to have cardioprotective and neuroprotective effects. It has also been shown to promote cardiomyocyte survival and plays an essential role in the development of neural tissue (López-Yoldi et al.).
Subtype
Cytokines
Alternative Names
CT-1, CTF1
Cell Type
Cardiomyocytes, PSC-Derived, Hepatic Cells, Prostate Cells
Species
Human
Area of Interest
Stem Cell Biology
Molecular Weight
21.1 kDa
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant Cardiotrophin-1
Catalog #
78160, 78160.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant Cardiotrophin-1
Catalog #
78160, 78160.1
Lot #
All
Language
English

Educational Materials(4)

Brochure
Reliable Antibodies for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant Cardiotrophin-1 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.4 ng/mL. (B) 2 μg of Human Recombinant Cardiotrophin-1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Cardiotrophin-1 has a predicted molecular mass of 21.1 kDa.

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