TMRE (Perchlorate)

Cell-permeant, cationic fluorescent dye used to measure mitochondrial membrane potential

TMRE (Perchlorate)

Cell-permeant, cationic fluorescent dye used to measure mitochondrial membrane potential

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Cell-permeant, cationic fluorescent dye used to measure mitochondrial membrane potential
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Overview

Detect changes in mitochondrial membrane potential with TMRE (Perchlorate) dye. TMRE uses a quick and simple staining protocol that is well suited for high-throughput screening and is compatible with flow cytometry.

Features:
• Excitation wavelength: 552 nm
• Emission wavelength: 574 nm
• Retention dependent on mitochondrial inner membrane potential
• Verified for use with flow cytometry

TMRE is a cell-permeant, cationic compound that emits a fluorescent red-orange signal. It readily accumulates in the mitochondria with high membrane potential, whereas depolarized mitochondria fail to retain the dye.

TMRE has a sufficient retention time that is optimal for cell sorting for further purification and characterization (Barteneva et al. J Histochem Cytochem, 2014). TMRE does not inhibit the mitochondrial function, and can be used in the identification of apoptotic cells (Barteneva et al., 2014).
Application
Flow Cytometry
CAS Number
115532-52-0

Data Figures

Figure 1. TMRE (Perchlorate) Is Not Retained in Apoptotic Cells

Flow cytometry analysis of Jurkat cells labeled with TMRE after incubation in the presence or absence of staurosporine, an inducer of apoptosis.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0992
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0992
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.