Anti-SHIP2 Antibody, Polyclonal

Rabbit polyclonal antibody against human, mouse SHIP2

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Rabbit polyclonal antibody against human, mouse SHIP2
384 USD

Overview

SHIP2 is a 145 kDa SHIP-related protein expressed in both hematopoietic and nonhematopoietic cells. Like SH2-containing inositol phosphatase (SHIP), SHIP2 becomes tyrosine phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP2 also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP2 protein.
Subtype:
Primary Antibodies
Target Antigen:
SHIP2
Alternative Names:
Inositol polyphosphate phosphatase like 1, INPPL1, OPSMD
Reactive Species:
Mouse; Human
Conjugation:
Unconjugated
Host Species:
Rabbit
Cell Type:
Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application:
Immunoblotting; Immunoprecipitation
Area of Interest:
Immunology
Clone:
Not applicable
Gene ID:
3636 (human), 16332 (mouse)
Isotype:
Not applicable

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Data and Publications

Data

Western blot analysis of total cell lysates (TCL) from human TF-1 cells, mouse WEHI-231 B cells, and mouse bone marrow derived mast cells (BMMCs) of SHIP +/+ and SHIP -/- mice with Anti-SHIP2 Antibody, Polyclonal (1:1000 dilution). The last two lanes represent anti-SHIP2 immunoprecipitates (IP) of 1 x 107 TF-1 cells and WEHI-231 B cells, respectively. SHIP2 has a predicted molecular mass of 145 kDa.

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