Anti-SHIP (C-Terminus) Antibody, Polyclonal

Rabbit polyclonal antibody against human, mouse SHIP

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Rabbit polyclonal antibody against human, mouse SHIP
403 USD

Overview

SHIP (C-terminus) is critical for the function of SHIP protein. SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP protein.
Subtype:
Primary Antibodies
Target Antigen:
SHIP
Alternative Names:
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; p150Ship; SHIP1; SHIP-1; s-SHIP; SIP-145
Reactive Species:
Mouse; Human
Conjugation:
Unconjugated
Host Species:
Rabbit
Cell Type:
Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application:
Immunoblotting; Immunoprecipitation
Area of Interest:
Immunology
Clone:
Not applicable
Gene ID:
3635 (human), 16331 (mouse)
Isotype:
Not applicable

Scientific Resources

Educational Materials

(2)

Data and Publications

Data

Western blot analysis of total cell lysates from human TF-1 cells (lane 1), mouse WEHI-231 cells (lane 2) and mouse bone marrow derived mast cells (BMMCs; lane 3) with Anti-SHIP (C-Terminus) Antibody, Polyclonal (1:1000 dilution). SHIP has a predicted molecular mass of 145 kDa.

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