Anti-Mouse EPCR Antibody, Clone RMEPCR1560 (1560)

Rat monoclonal IgG2b antibody against mouse EPCR (CD201)

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Rat monoclonal IgG2b antibody against mouse EPCR (CD201)
From: 159 USD

Overview Related Products Scientific Resources Product Applications Data and Publications

Overview

The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family. EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation. EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity. Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs.
Subtype:
Primary Antibodies
Target Antigen:
EPCR (CD201)
Alternative Names:
Activated protein C receptor, APC receptor, CCD41, CD201, endothelial protein C receptor, PROCR, protein C receptor
Reactive Species:
Mouse
Conjugation:
Biotin; FITC; PE; Unconjugated
Host Species:
Rat
Cell Type:
Hematopoietic Stem and Progenitor Cells; Endothelial Cells
Application:
Cell Isolation; Flow Cytometry; Functional Assay; Immunohistochemistry; Western Blotting
Area of Interest:
Stem Cell Biology; Endothelial Cell Biology
Clone:
RMEPCR1560 (1560)
Gene ID:
19124
Isotype:
IgG2b, kappa

Scientific Resources

Product Documentation

Educational Materials

(3)
Brochure
Hematopoietic Stem and Progenitor Cells - Products for Your Research
Brochure
Complete Antibody Listing
Brochure
Cell Culture Antibodies

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area Workflow Stages for
Workflow Stages
Hematopoietic Stem and Progenitor Cell Research
Cell Sourcing and Isolation
Expansion and Differentiation
Analysis

Data and Publications

Data

Data for Unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control; dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI). Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC is shown (solid line histogram).

Data for Biotin-Conjugated

Figure 2. Data for Biotin-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, Biotin followed by streptavidin (SAV) APC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody followed by SAV APC is shown (solid line histogram).

Data for FITC-Conjugated

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560 FITC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa FITC isotype control antibody is shown (solid line histogram).

Data for PE-Conjugated

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, PE. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa PE isotype control antibody is shown (solid line histogram).

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.