Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1

Rat monoclonal IgG1 antibody against human, mouse, dog E­cadherin (CD324)

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From: 143 USD

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Rat monoclonal IgG1 antibody against human, mouse, dog E­cadherin (CD324)
From: 143 USD

Overview

The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.
Subtype:
Primary Antibodies
Target Antigen:
E-Cadherin (CD324)
Alternative Names:
Arc 1, Cadherin-1, CAM 120/80, CDHE, CDH1, E-Cad/CTF3, Epithelial cadherin, epithelial calcium-dependent adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin
Reactive Species:
Human; Mouse; Pig; Dog
Conjugation:
Unconjugated
Host Species:
Rat
Cell Type:
Airway Cells
Application:
Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunoprecipitation; Western Blotting; Functional Assay
Area of Interest:
Endothelial Cell Biology
Clone:
DECMA-1
Gene ID:
999/12550
Isotype:
IgG1, kappa

Scientific Resources

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Data and Publications

Data

(A) Primary human airway epithelial cells were expanded in a submerged culture with PneumaCult™-Ex Medium (Catalog #05008). The cells were labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488, and counterstained with DAPI. (B) Flow cytometry analysis of MDCK epithelial cells labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by an anti-rat IgG1 antibody, PE (filled histogram) or Rat IgG1, kappa Isotype Control Antibody, Clone RTK2071 (Catalog #60075), followed by an anti-rat IgG1 antibody, PE (dotted line histogram).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.