Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4

Rat monoclonal IgG2b antibody against mouse CD54

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Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4

Rat monoclonal IgG2b antibody against mouse CD54, unconjugated

500 µg
Catalog #60151
222 USD

Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4

Rat monoclonal IgG2b antibody against mouse CD54, unconjugated

50 µg
Catalog #60151.1
70 USD

Overview

The YN1/1.7.4 antibody reacts with CD54, a 90 - 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily. CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing. As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules. Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-γ.
Subtype:
Primary Antibodies
Target Antigen:
CD54 (ICAM-1)
Alternative Names:
BB2, Cell surface glycoprotein P3.58, Human rhinovirus receptor, Intercellular adhesion molecule 1, Ly-47, MALA2, MyD10
Reactive Species:
Mouse
Conjugation:
Unconjugated
Host Species:
Rat
Cell Type:
Endothelial Cells
Application:
Cell Isolation; Flow Cytometry; Immunoblotting; Immunoprecipitation
Area of Interest:
Immunology
Clone:
YN1/1.7.4
Gene ID:
15894
Isotype:
IgG2b, kappa

Scientific Resources

Educational Materials

(3)

Data and Publications

Data

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN/1.7.4, followed by a mouse anti-rat IgG2b antibody, FITC (filled histogram) or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530 (Catalog #60077), followed by a mouse anti-rat IgG2b antibody, FITC (solid line histogram).

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